Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial.
Int J Clin Pract
; 2023: 9528335, 2023.
Article
in En
| MEDLINE
| ID: mdl-37101856
ABSTRACT
Objective:
Female sexual dysfunction is a common distressing problem among women, which may result from reducing circulating endogenous estrogen. Humulus lupulus L. (hop) has antioxidant, anti-inflammatory, anticancer, and estrogenic properties. Therefore, this study aimed to assess the efficacy of hop on postmenopausal sexual dysfunction.Methods:
In the current randomized clinical trial, study populations consisted of 63 postmenopausal women who were randomly categorized into two groups. In the hop group (N = 33), women received the vaginal gel containing Hop extract every day for seven days and then continued for two months, twice weekly. In the estradiol group (N = 30), women were treated with vaginal estradiol (0.625 mg) over two 28-day cycles (21 days of therapy and seven days rest). The sexual function was evaluated using the Female Sexual Function Index (FSFI) questionnaire before and after intervention.Results:
No statistically significant differences in FSFI scores (sexual desire, sexual arousal, vaginal lubrication, satisfaction, orgasm, sexual pain, and total FSFI) (P > 0.05) were noticed after treatment between the hop and estradiol groups.Conclusion:
Vaginal hop was as effective as estradiol in improving the sexual dysfunction among postmenopausal women with no adverse events. This trial is registered with IRCT20210405050859N1.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sexual Dysfunction, Physiological
/
Humulus
Type of study:
Clinical_trials
Limits:
Female
/
Humans
Language:
En
Journal:
Int J Clin Pract
Journal subject:
MEDICINA
Year:
2023
Type:
Article
Affiliation country:
Iran