Antibody-mediated regulation of basophils: emerging views and clinical implications.
Trends Immunol
; 44(6): 408-423, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37147229
ABSTRACT
An increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in the context of type 2 immunity and allergic inflammation; however, growing evidence shows that IgG, IgA, and IgD also shape specific aspects of basophil functions relevant to many human diseases. We discuss recent mechanistic advances underpinning antibody-mediated basophil responses and propose strategies for the treatment of basophil-associated disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Basophils
/
Hypersensitivity
Limits:
Humans
Language:
En
Journal:
Trends Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2023
Type:
Article