Ocrelizumab-treated patients with relapsing multiple sclerosis show volume loss rates similar to healthy aging.
Mult Scler
; 29(6): 741-747, 2023 05.
Article
in En
| MEDLINE
| ID: mdl-37148240
ABSTRACT
BACKGROUND:
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by two major and interconnected hallmarks inflammation and progressive neurodegeneration.OBJECTIVE:
The aim of this work was to compare neurodegenerative processes, in the form of global and regional brain volume loss rates, in healthy controls (HCs) and in patients with relapsing MS (RMS) treated with ocrelizumab, which suppresses acute inflammation.METHODS:
Whole brain, white matter, cortical gray matter, thalamic, and cerebellar volume loss rates were assessed in 44 HCs that were part of a substudy in the OPERA II randomized controlled trial (NCT01412333) and 59 patients with RMS enrolled in the same substudy as well as age- and sex-matched patients in OPERA I (NCT01247324) and II. Volume loss rates were computed using random coefficients models over a period of 2 years.RESULTS:
Ocrelizumab-treated patients showed global and regional brain volume loss rates that were approaching that of HCs.CONCLUSION:
These findings are consistent with an important role of inflammation on overall tissue loss and the role of ocrelizumab in reducing this phenomenon.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Multiple Sclerosis, Chronic Progressive
/
Multiple Sclerosis, Relapsing-Remitting
/
Healthy Aging
/
Multiple Sclerosis
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2023
Type:
Article
Affiliation country:
Canada