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Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells.
Islam, Mohammad Shahidul; Al-Majid, Abdullah Mohammed; Sholkamy, Essam Nageh; Barakat, Assem; Viale, Maurizio; Menichini, Paola; Speciale, Andrea; Loiacono, Fabrizio; Azam, Mohammad; Verma, Ved Prakash; Yousuf, Sammer; Teleb, Mohamed.
Affiliation
  • Islam MS; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
  • Al-Majid AM; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
  • Sholkamy EN; Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
  • Barakat A; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. ambarakat@ksu.edu.sa.
  • Viale M; U.O.C. Bioterapie, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genova, Italy.
  • Menichini P; U.O.C. Mutagenesi e Prevenzione Oncologica, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genova, Italy.
  • Speciale A; U.O.C. Mutagenesi e Prevenzione Oncologica, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genova, Italy.
  • Loiacono F; U.O.C. Immunologia, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genova, Italy.
  • Azam M; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
  • Verma VP; Department of Chemistry, Banasthali Vidyapith, Banasthali, 304022, Rajasthan, India.
  • Yousuf S; H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
  • Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. mohamed.t.ismail@alexu.edu.eg.
Sci Rep ; 13(1): 7441, 2023 05 08.
Article in En | MEDLINE | ID: mdl-37156796
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Antineoplastic Agents Type of study: Guideline Limits: Female / Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Saudi Arabia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Antineoplastic Agents Type of study: Guideline Limits: Female / Humans Language: En Journal: Sci Rep Year: 2023 Type: Article Affiliation country: Saudi Arabia