Complementary methods for monitoring hole-hole homodimer associated with a WuXiBody-based asymmetric bispecific antibody.

Dong, Wanyuan; Li, Yifeng

Dong, Wanyuan; Li, Yifeng.

Affiliation

Dong W; Downstream Process Development (DSPD), WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, China.
Li Y; Downstream Process Development (DSPD), WuXi Biologics, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai, 200131, China. Electronic address: li_yifeng@wuxibiologics.com.

Protein Expr Purif ; 210: 106316, 2023 10.

Article in En | MEDLINE | ID: mdl-37271410

Subject(s)

Antibodies, Bispecific; Chromatography; Dimerization; Antibodies, Bispecific/chemistry

Key words

Bispecific antibody (bsAb); CaptureSelect CH1-XL; Cation exchange (CEX); Hydrophobic interaction chromatography (HIC); KappaSelect; Knobs-into-holes (KiH); Protein L; Reverse phase (RP); WuXiBody

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatography / Antibodies, Bispecific Type of study: Risk_factors_studies Language: En Journal: Protein Expr Purif Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: China

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