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Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.
Gordhan, Heeren M; Miller, Steven T; Clancy, Daphne C; Ina, Maria; McDougal, Alan V; Cutno, D'Quan K; Brown, Robert V; Lichorowic, Cynthia L; Sturdivant, Jill M; Vick, Kyle A; Williams, Stuart S; deLong, Mitchell A; White, Jeffrey C; Kopczynski, Casey C; Ellis, David A.
Affiliation
  • Gordhan HM; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Miller ST; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Clancy DC; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Ina M; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • McDougal AV; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Cutno DK; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Brown RV; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Lichorowic CL; Sage Therapeutics, Inc., Boston, Massachusetts 02142, United States.
  • Sturdivant JM; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Vick KA; ID Business Solutions, Ltd., Boston, Massachusetts 02210, United States.
  • Williams SS; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • deLong MA; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • White JC; Baxter Healthcare Corp., Deerfield, Illinois 60015, United States.
  • Kopczynski CC; Alcon Research, LLC, Durham, North Carolina 27703, United States.
  • Ellis DA; Alcon Research, LLC, Durham, North Carolina 27703, United States.
J Med Chem ; 66(13): 8929-8950, 2023 07 13.
Article in En | MEDLINE | ID: mdl-37314941
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Janus Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Janus Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States