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Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.
Xiao, Zili; Yang, Michael G; Liu, Chunjian; Sherwood, Trevor; Gilmore, John L; Lin, James; Li, Peng; Wu, Dauh-Rurng; Tokarski, John; Li, Sha; Cheng, Lihong; Xie, Chunshan; Fan, Jingsong; Dierks, Elizabeth; Strnad, Joann; Cvijic, Mary Ellen; Khan, Javed; Ruzanov, Max; Galella, Michael; Khandelwal, Purnima; Dyckman, Alaric J; Mathur, Arvind; Lombardo, Louis J; Macor, John E; Carter, Percy H; Aranibar, Nelly; Burke, James R; Weinstein, David S.
Affiliation
  • Xiao Z; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States. Electronic address: zili.xiao@bms.com.
  • Yang MG; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Liu C; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Sherwood T; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Gilmore JL; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Lin J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Li P; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Wu DR; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Tokarski J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Li S; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Cheng L; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Xie C; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Fan J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Dierks E; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Strnad J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Cvijic ME; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Khan J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Ruzanov M; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Galella M; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Khandelwal P; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Dyckman AJ; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Mathur A; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Lombardo LJ; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Macor JE; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Carter PH; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Aranibar N; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Burke JR; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Weinstein DS; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
Bioorg Med Chem Lett ; 91: 129373, 2023 07 15.
Article in En | MEDLINE | ID: mdl-37315697
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / TYK2 Kinase Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / TYK2 Kinase Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Type: Article