Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis.
J Neuroimmunol
; 381: 578128, 2023 08 15.
Article
in En
| MEDLINE
| ID: mdl-37321014
ABSTRACT
Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Necrosis Factor Receptor Superfamily, Member 7
/
Multiple Sclerosis, Relapsing-Remitting
/
Multiple Sclerosis
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Neuroimmunol
Year:
2023
Type:
Article