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The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells.
Zhou, Min; Boulos, Joelle C; Klauck, Sabine M; Efferth, Thomas.
Affiliation
  • Zhou M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University-Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
  • Boulos JC; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University-Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
  • Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), National Center for Tumor Disease (NCT), 69120, Heidelberg, Germany.
  • Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University-Mainz, Staudinger Weg 5, 55128, Mainz, Germany. efferth@uni-mainz.de.
Cell Biol Toxicol ; 39(6): 2971-2997, 2023 12.
Article in En | MEDLINE | ID: mdl-37322258
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiac Glycosides / Leukemia / Parthanatos Limits: Humans Language: En Journal: Cell Biol Toxicol Journal subject: TOXICOLOGIA Year: 2023 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiac Glycosides / Leukemia / Parthanatos Limits: Humans Language: En Journal: Cell Biol Toxicol Journal subject: TOXICOLOGIA Year: 2023 Type: Article Affiliation country: Germany