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Stressing the role of a short linear motif in ataxin-2 condensation.
Scheidt, Tom; Ruan, Hao; Yu, Miao; Lemke, Edward A.
Affiliation
  • Scheidt T; Biocenter, Johannes Gutenberg University, Hanns-Dieter-Hüsch Weg 17, 55128 Mainz, Germany; Institute for Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
  • Ruan H; Biocenter, Johannes Gutenberg University, Hanns-Dieter-Hüsch Weg 17, 55128 Mainz, Germany; Institute for Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
  • Yu M; Biocenter, Johannes Gutenberg University, Hanns-Dieter-Hüsch Weg 17, 55128 Mainz, Germany; Institute for Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
  • Lemke EA; Biocenter, Johannes Gutenberg University, Hanns-Dieter-Hüsch Weg 17, 55128 Mainz, Germany; Institute for Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany. Electronic address: edlemke@uni-mainz.de.
Mol Cell ; 83(12): 1961-1963, 2023 Jun 15.
Article in En | MEDLINE | ID: mdl-37327772
ABSTRACT
Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al.1 identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress response.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Ataxin-2 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurodegenerative Diseases / Ataxin-2 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: Germany