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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Solvay, Marie; Holfelder, Pauline; Klaessens, Simon; Pilotte, Luc; Stroobant, Vincent; Lamy, Juliette; Naulaerts, Stefan; Spillier, Quentin; Frédérick, Raphaël; De Plaen, Etienne; Sers, Christine; Opitz, Christiane A; Van den Eynde, Benoit J; Zhu, Jingjing.
Affiliation
  • Solvay M; de Duve Institute, UCLouvain, Brussels, Belgium.
  • Holfelder P; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
  • Klaessens S; Faculty of Bioscience, Heidelberg University, Heidelberg, Germany.
  • Pilotte L; DKTK Division of Metabolic Crosstalk in Cancer, German Cancer Research Center, DKFZ, INF 280, 69120 Heidelberg, Germany.
  • Stroobant V; de Duve Institute, UCLouvain, Brussels, Belgium.
  • Lamy J; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
  • Naulaerts S; de Duve Institute, UCLouvain, Brussels, Belgium.
  • Spillier Q; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
  • Frédérick R; de Duve Institute, UCLouvain, Brussels, Belgium.
  • De Plaen E; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
  • Sers C; de Duve Institute, UCLouvain, Brussels, Belgium.
  • Opitz CA; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
  • Van den Eynde BJ; de Duve Institute, UCLouvain, Brussels, Belgium.
  • Zhu J; Ludwig Institute for Cancer Research, de Duve Institute, Brussels, Belgium.
J Immunother Cancer ; 11(6)2023 06.
Article in En | MEDLINE | ID: mdl-37344101
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Kynurenine Limits: Animals / Humans Language: En Journal: J Immunother Cancer Year: 2023 Type: Article Affiliation country: Belgium
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Kynurenine Limits: Animals / Humans Language: En Journal: J Immunother Cancer Year: 2023 Type: Article Affiliation country: Belgium