Inhibition of talin-induced integrin activation by a double-hit stapled peptide.

Gao, Tong; Cho, Eun-Ah; Zhang, Pingfeng; Wu, Jinhua

Gao, Tong; Cho, Eun-Ah; Zhang, Pingfeng; Wu, Jinhua.

Affiliation

Gao T; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Cho EA; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Zhang P; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Wu J; Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: jinhua.wu@fccc.edu.

Structure ; 31(8): 948-957.e3, 2023 08 03.

Article in En | MEDLINE | ID: mdl-37369205

Subject(s)

Peptidomimetics; Talin; Talin/chemistry; Adaptor Proteins, Signal Transducing/chemistry; Membrane Proteins/chemistry; Peptidomimetics/pharmacology; Integrins/metabolism; Peptides/pharmacology; Peptides/metabolism

Key words

RIAM; crystal structure; integrin; peptidomimetic inhibitor; stapled peptide; talin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Talin / Peptidomimetics Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2023 Type: Article Affiliation country: United States

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