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Genetic Associations with Coronavirus Susceptibility and Disease Severity.
Barmania, Fatima; Mellet, Juanita; Holborn, Megan A; Pepper, Michael S.
Affiliation
  • Barmania F; Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Mellet J; Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Holborn MA; Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Pepper MS; Institute for Cellular and Molecular Medicine, Department of Immunology, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. michael.pepper@up.ac.za.
Adv Exp Med Biol ; 1412: 119-140, 2023.
Article in En | MEDLINE | ID: mdl-37378764
ABSTRACT
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global public health emergency, and the disease it causes is highly variable in its clinical presentation. Host genetic factors are increasingly recognised as a determinant of infection susceptibility and disease severity. Several initiatives and groups have been established to analyse and review host genetic epidemiology associated with COVID-19 outcomes. Here, we review the genetic loci associated with COVID-19 susceptibility and severity focusing on the common variants identified in genome-wide association studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Adv Exp Med Biol Year: 2023 Type: Article Affiliation country: South Africa
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Adv Exp Med Biol Year: 2023 Type: Article Affiliation country: South Africa