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HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV.
Benner, Sarah E; Zhu, Xianming; Hussain, Sarah; Florman, Sander; Eby, Yolanda; Fernandez, Reinaldo E; Ostrander, Darin; Rana, Meenakshi; Ottmann, Shane; Hand, Jonathan; Price, Jennifer C; Pereira, Marcus R; Wojciechowski, David; Simkins, Jacques; Stosor, Valentina; Mehta, Sapna A; Aslam, Saima; Malinis, Maricar; Haidar, Ghady; Massie, Allan; Smith, Melissa L; Odim, Jonah; Morsheimer, Megan; Quinn, Thomas C; Laird, Gregory M; Siliciano, Robert; Balagopal, Ashwin; Segev, Dorry L; Durand, Christine M; Redd, Andrew D; Tobian, Aaron A R.
Affiliation
  • Benner SE; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Zhu X; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Hussain S; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Florman S; Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Eby Y; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Fernandez RE; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Ostrander D; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Rana M; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Ottmann S; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hand J; Department of Infectious Diseases, Ochsner Health, New Orleans, Louisiana, USA.
  • Price JC; Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Pereira MR; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Wojciechowski D; Division of Nephrology, University of Texas Southwestern, Dallas, Texas, USA.
  • Simkins J; Department of Medicine/Division of Infectious Diseases, University of Miami School of Medicine, Miami, Florida, USA.
  • Stosor V; Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Mehta SA; Department of Medicine, New York University Grossman School of Medicine, New York University Langone Health, New York, New York, USA.
  • Aslam S; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California, USA.
  • Malinis M; Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Haidar G; Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Massie A; Department of Surgery, New York University Grossman School of Medicine, New York University Langone Health, New York, New York, USA.
  • Smith ML; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky, USA.
  • Odim J; Division of Extramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Morsheimer M; Division of Extramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Quinn TC; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Laird GM; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Siliciano R; Accelevir Diagnostics, Baltimore, Maryland, USA.
  • Balagopal A; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Segev DL; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Durand CM; Department of Surgery, New York University Grossman School of Medicine, New York University Langone Health, New York, New York, USA.
  • Redd AD; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Tobian AAR; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
J Infect Dis ; 228(9): 1274-1279, 2023 11 02.
Article in En | MEDLINE | ID: mdl-37379584
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV Seropositivity / Liver Transplantation Limits: Humans Language: En Journal: J Infect Dis Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV Seropositivity / Liver Transplantation Limits: Humans Language: En Journal: J Infect Dis Year: 2023 Type: Article Affiliation country: United States