Uncovering neuroanatomical correlates of impaired coordinated movement after pallidal deep brain stimulation.
J Neurol Neurosurg Psychiatry
; 95(2): 167-170, 2024 Jan 11.
Article
in En
| MEDLINE
| ID: mdl-37438098
ABSTRACT
BACKGROUND:
The loss of the ability to swim following deep brain stimulation (DBS), although rare, poses a worrisome risk of drowning. It is unclear what anatomic substrate and neural circuitry underlie this phenomenon. We report a case of cervical dystonia with lost ability to swim and dance during active stimulation of globus pallidus internus. We investigated the anatomical underpinning of this phenomenon using unique functional and structural imaging analysis.METHODS:
Tesla (3T) functional MRI (fMRI) of the patient was used during active DBS and compared with a cohort of four matched patients without this side effect. Structural connectivity mapping was used to identify brain network engagement by stimulation.RESULTS:
fMRI during stimulation revealed significant (Pbonferroni<0.0001) stimulation-evoked responses (DBS ONCONCLUSIONS:
These stimulation-induced impairments are likely a manifestation of a broader deficit in interlimb coordination mediated by stimulation effects on the SMA. This neuroanatomical underpinning can help inform future patient-specific stimulation and targeting.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Deep Brain Stimulation
/
Globus Pallidus
Limits:
Humans
Language:
En
Journal:
J Neurol Neurosurg Psychiatry
Year:
2024
Type:
Article
Affiliation country:
Canada