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Open and Closed Triple Inhaler Therapy in Patients with Uncontrolled Asthma.
Kotoulas, Serafeim-Chrysovalantis; Tsiouprou, Ioanna; Domvri, Kalliopi; Ntontsi, Polyxeni; Pataka, Athanasia; Porpodis, Konstantinos.
Affiliation
  • Kotoulas SC; ICU, General Hospital of Thessaloniki "Hippokration", 49th Kostantinoupoleos Street, 57642 Thessaloniki, Greece.
  • Tsiouprou I; Pulmonary Clinic of Aristotle University of Thessaloniki, General Hospital of Thessaloniki "Georgios Papanikolaou", Leoforos Papanikolaou, Exohi, 57010 Thessaloniki, Greece.
  • Domvri K; Laboratory of Histology-Embryology, Medical School, Aristotle University of Thessaloniki, Leoforos Agiou Dimitriou, 54124 Thessaloniki, Greece.
  • Ntontsi P; 2nd University Department of Respiratory Medicine, Attikon Hospital, 1st Rimini Street, Haidari,12462 Athens, Greece.
  • Pataka A; Respiratory Failure Clinic of Aristotle University of Thessaloniki, General Hospital of Thessaloniki "Georgios Papanikolaou", Leoforos Papanikolaou, Exohi, 57010 Thessaloniki, Greece.
  • Porpodis K; Pulmonary Clinic of Aristotle University of Thessaloniki, General Hospital of Thessaloniki "Georgios Papanikolaou", Leoforos Papanikolaou, Exohi, 57010 Thessaloniki, Greece.
Adv Respir Med ; 91(4): 288-300, 2023 Jul 04.
Article in En | MEDLINE | ID: mdl-37489386
ABSTRACT
Long-acting muscarinic antagonists (LAMAs) are a class of inhalers that has recently been included as add-on therapy in the GINA guidelines, either in a single inhaler device with inhaled corticosteroids plus long-acting ß2-agonists (ICS + LABA) (closed triple inhaler therapy) or in a separate one (open triple inhaler therapy). This review summarizes the existing evidence on the addition of LAMAs in patients with persistently uncontrolled asthma despite ICS + LABA treatment based on clinical efficacy in the reduction of asthma symptoms and exacerbations, the improvement in lung function, and its safety profile.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Adrenergic beta-2 Receptor Agonists Type of study: Guideline Limits: Humans Language: En Journal: Adv Respir Med Year: 2023 Type: Article Affiliation country: Greece
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Adrenergic beta-2 Receptor Agonists Type of study: Guideline Limits: Humans Language: En Journal: Adv Respir Med Year: 2023 Type: Article Affiliation country: Greece