NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.
Mol Cell
; 83(15): 2621-2623, 2023 08 03.
Article
in En
| MEDLINE
| ID: mdl-37541218
ABSTRACT
Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al.1 implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pathogen-Associated Molecular Pattern Molecules
/
Heme
Limits:
Humans
Language:
En
Journal:
Mol Cell
Journal subject:
BIOLOGIA MOLECULAR
Year:
2023
Type:
Article
Affiliation country:
Switzerland