Your browser doesn't support javascript.
loading
NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation.
Bernard, Elliott M; Broz, Petr.
Affiliation
  • Bernard EM; Department of Immunobiology, University of Lausanne, Lausanne, Switzerland.
  • Broz P; Department of Immunobiology, University of Lausanne, Lausanne, Switzerland. Electronic address: petr.broz@unil.ch.
Mol Cell ; 83(15): 2621-2623, 2023 08 03.
Article in En | MEDLINE | ID: mdl-37541218
ABSTRACT
Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al.1 implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pathogen-Associated Molecular Pattern Molecules / Heme Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: Switzerland
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pathogen-Associated Molecular Pattern Molecules / Heme Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2023 Type: Article Affiliation country: Switzerland