Effect of Material Properties and Variability of Mannitol on Tablet Formulation Development.

Liu, Jiaying; Klinzing, Gerard R; Nie, Haichen

Liu, Jiaying; Klinzing, Gerard R; Nie, Haichen.

Affiliation

Liu J; Pharmaceutical Sciences, Merck & Co., Inc, 126 E. Lincoln Ave, Rahway, NJ, 07065, USA.
Klinzing GR; Pharmaceutical Sciences, Merck & Co., Inc, 126 E. Lincoln Ave, Rahway, NJ, 07065, USA.
Nie H; Pharmaceutical Sciences, Merck & Co., Inc, 126 E. Lincoln Ave, Rahway, NJ, 07065, USA. niehaichen@gmail.com.

Pharm Res ; 40(8): 2071-2085, 2023 Aug.

Article in En | MEDLINE | ID: mdl-37552385

Subject(s)

Mannitol; Mechanical Phenomena; Mannitol/chemistry; Chemical Phenomena; Excipients/chemistry; Tensile Strength; Tablets/chemistry; Drug Compounding; Particle Size; Powders/chemistry

Key words

Chipping; Mannitol crystalline form; Physical properties; Specific surface area; Tablet strength

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mechanical Phenomena / Mannitol Language: En Journal: Pharm Res Year: 2023 Type: Article Affiliation country: United States

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