Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase.

Bradic, Ivan; Liesinger, Laura; Kuentzel, Katharina B; Vujic, Nemanja; Trauner, Michael; Birner-Gruenberger, Ruth; Kratky, Dagmar

Bradic, Ivan; Liesinger, Laura; Kuentzel, Katharina B; Vujic, Nemanja; Trauner, Michael; Birner-Gruenberger, Ruth; Kratky, Dagmar.

Affiliation

Bradic I; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Liesinger L; Institute of Chemical Technologies and Analytics, TU Wien, Vienna, Austria.
Kuentzel KB; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Vujic N; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Trauner M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Birner-Gruenberger R; Institute of Chemical Technologies and Analytics, TU Wien, Vienna, Austria; BioTechMed-Graz, Graz, Austria; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria. Electronic address: ruth.birner-gruenberger@tuwien.ac.at.
Kratky D; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address: dagmar.kratky@medunigraz.at.

J Lipid Res ; 64(9): 100427, 2023 09.

Article in En | MEDLINE | ID: mdl-37595802

Subject(s)

Neoplasms; Non-alcoholic Fatty Liver Disease; Wolman Disease; Mice; Animals; Sterol Esterase/genetics; Sterol Esterase/metabolism; Non-alcoholic Fatty Liver Disease/metabolism; Proteome/genetics; Proteome/metabolism; Proteomics; Liver/metabolism; Wolman Disease/genetics; Wolman Disease/metabolism; Wolman Disease/pathology; Liver Cirrhosis/genetics; Triglycerides/metabolism; Inflammation/metabolism; Neoplasms/metabolism

Key words

cholesterol; cholesterol ester storage disease; lipase/lysosomal; lipid metabolism; lipids; liver; lysosomal storage disorder; non-alcoholic fatty liver disease; proteomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wolman Disease / Non-alcoholic Fatty Liver Disease / Neoplasms Limits: Animals Language: En Journal: J Lipid Res Year: 2023 Type: Article Affiliation country: Austria

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