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Comprehensive profiling of DNA methylation in Korean patients with colorectal cancer.
Shim, Hyeran; Jang, Kiwon; Bang, Yeong Hak; Chu, Hoang Bao Khanh; Kang, Jisun; Lee, Jin-Young; Cho, Sheehyun; Lee, Hong Seok; Jeon, Jongbum; Hwang, Taeyeon; Joe, Soobok; Lim, Jinyeong; Choi, Ji-Hye; Joo, Eun Hye; Park, Kyunghee; Moon, Ji Hwan; Han, Kyung Yeon; Hong, Yourae; Lee, Woo Yong; Kim, Hee Cheol; Yun, Seong Hyeon; Cho, Yong Beom; Park, Yoon Ah; Huh, Jung Wook; Shin, Jung Kyong; Pyo, Dae Hee; Hong, Hyekyung; Lee, Hae-Ock; Park, Woong-Yang; Yang, Jin Ok; Kim, Young-Joon.
Affiliation
  • Shim H; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Jang K; Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • Bang YH; Department of Digital Health, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06355; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Chu HBK; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Kang J; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Lee JY; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Cho S; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Lee HS; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
  • Jeon J; Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • Hwang T; Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • Joe S; Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • Lim J; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355, Korea.
  • Choi JH; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355, Korea.
  • Joo EH; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355, Korea.
  • Park K; Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Moon JH; Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Han KY; Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Hong Y; Department of Oncology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
  • Lee WY; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Kim HC; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Yun SH; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Cho YB; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Park YA; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Huh JW; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Shin JK; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Pyo DH; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Hong H; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Lee HO; Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591; Department of Biomedicine and Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea.
  • Park WY; Department of Digital Health, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06355; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul 06355; Samsung Geno
  • Yang JO; Korea Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  • Kim YJ; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722; LepiDyne Co., Ltd., Seoul 04779, Korea.
BMB Rep ; 57(2): 110-115, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37605617
ABSTRACT
Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), and conducted an in-depth investigation of cancer-specific methylation patterns. Our analysis of the tumor samples revealed a significant presence of hypomethylated probes, primarily within the gene body regions; few hypermethylated sites were observed, which were mostly enriched in promoter-like and CpG island regions. The CpG Island Methylator PhenotypeHigh (CIMP-H) exhibited notable enrichment of microsatellite instability-high (MSI-H). Additionally, our findings indicated a significant correlation between methylation of the MLH1 gene and MSI-H status. Furthermore, we found that the CIMP-H had a higher tendency to affect the right-side of the colon tissues and was slightly more prevalent among older patients. Through our methylome profile analysis, we successfully verified the thylation patterns and clinical characteristics of Korean patients with CRC. This valuable dataset lays a strong foundation for exploring novel molecular insights and potential therapeutic targets for the treatment of CRC. [BMB Reports 2024; 57(2) 110-115].
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / DNA Methylation Limits: Humans Country/Region as subject: Asia Language: En Journal: BMB Rep Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / DNA Methylation Limits: Humans Country/Region as subject: Asia Language: En Journal: BMB Rep Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2024 Type: Article