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PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors.
Gill, Amanda L; Wang, Peter H; Lee, Judong; Hudson, William H; Ando, Satomi; Araki, Koichi; Hu, Yinghong; Wieland, Andreas; Im, Sejin; Gavora, Autumn; Medina, Christopher B; Freeman, Gordon J; Hashimoto, Masao; Reiner, Steven L; Ahmed, Rafi.
Affiliation
  • Gill AL; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Wang PH; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Lee J; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Hudson WH; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Ando S; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  • Araki K; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  • Hu Y; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Wieland A; Department of Otolaryngology-Head and Neck Surgery, Ohio State University, Columbus, OH 43210, USA.
  • Im S; Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
  • Gavora A; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Medina CB; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Hashimoto M; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
  • Reiner SL; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
  • Ahmed R; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30329, USA.
Sci Immunol ; 8(86): eadg0539, 2023 08 04.
Article in En | MEDLINE | ID: mdl-37624909
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Programmed Cell Death 1 Receptor Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Immunol Year: 2023 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Programmed Cell Death 1 Receptor Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Immunol Year: 2023 Type: Article Affiliation country: United States