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CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study.
Neale, Isabel; Ali, Mohammad; Kronsteiner, Barbara; Longet, Stephanie; Abraham, Priyanka; Deeks, Alexandra S; Brown, Anthony; Moore, Shona C; Stafford, Lizzie; Dobson, Susan L; Plowright, Megan; Newman, Thomas A H; Wu, Mary Y; Carr, Edward J; Beale, Rupert; Otter, Ashley D; Hopkins, Susan; Hall, Victoria; Tomic, Adriana; Payne, Rebecca P; Barnes, Eleanor; Richter, Alex; Duncan, Christopher J A; Turtle, Lance; de Silva, Thushan I; Carroll, Miles; Lambe, Teresa; Klenerman, Paul; Dunachie, Susanna.
Affiliation
  • Neale I; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Ali M; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Kronsteiner B; Mahidol-Oxford Tropical Medicine Research Unit , Bangkok, Thailand.
  • Longet S; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Abraham P; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Deeks AS; Mahidol-Oxford Tropical Medicine Research Unit , Bangkok, Thailand.
  • Brown A; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Moore SC; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Stafford L; Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford , Oxford, United Kingdom.
  • Dobson SL; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford , Oxford, United Kingdom.
  • Plowright M; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Newman TAH; NDM Centre For Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Wu MY; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Carr EJ; Peter Medawar Building for Pathogen Research, Nuffield Department of Clinical Medicine, University of Oxford , Oxford, United Kingdom.
  • Beale R; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, United Kingdom.
  • Otter AD; Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford , Oxford, United Kingdom.
  • Hopkins S; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool, United Kingdom.
  • Hall V; Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, United Kingdom.
  • Tomic A; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield , Sheffield, United Kingdom.
  • Payne RP; Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield, United Kingdom.
  • Barnes E; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield , Sheffield, United Kingdom.
  • Richter A; Covid Surveillance Unit, The Francis Crick Institute , London, United Kingdom.
  • Duncan CJA; Covid Surveillance Unit, The Francis Crick Institute , London, United Kingdom.
  • Turtle L; The Francis Crick Institute , London, United Kingdom.
  • de Silva TI; The Francis Crick Institute , London, United Kingdom.
  • Carroll M; The Francis Crick Institute , London, United Kingdom.
  • Lambe T; UCL Department of Renal Medicine, Royal Free Hospital , London, United Kingdom.
  • Klenerman P; UK Health Security Agency , Porton Down, United Kingdom.
  • Dunachie S; UK Health Security Agency , London, United Kingdom.
mBio ; 14(5): e0121223, 2023 Oct 31.
Article in En | MEDLINE | ID: mdl-37655880
ABSTRACT
IMPORTANCE Defining correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infection informs vaccine policy for booster doses and future vaccine designs. Existing studies demonstrate humoral correlates of protection, but the role of T cells in protection is still unclear. In this study, we explore antibody and T cell immune responses associated with protection against Delta variant vaccine breakthrough infection in a well-characterized cohort of UK Healthcare Workers (HCWs). We demonstrate evidence to support a role for CD4+ and CD8+ T cells as well as antibodies against Delta vaccine breakthrough infection. In addition, our results suggest a potential role for cross-reactive T cells in vaccine breakthrough.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / Breakthrough Infections Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: MBio Year: 2023 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / Breakthrough Infections Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: MBio Year: 2023 Type: Article Affiliation country: United kingdom