PET-Derived Increased Inflammation in Large Vessels is linked to Relapse-Free Survival in Patients with Giant Cell Arteritis.
Nuklearmedizin
; 62(4): 229-234, 2023 Aug.
Article
in En
| MEDLINE
| ID: mdl-37666267
ABSTRACT
BACKGROUND:
Despite anti-inflammatory treatment, patients with giant cell arteritis (GCA) experience relapse. We aimed to determine respective relapse predictors focusing on [18F]fluorodeoxyglucose ([18F]FDG)-PET-based parameters. MATERIAL ANDMETHODS:
21 therapy-naïve GCA patients received [18F]FDG-PET/CT. Patients were divided in two groups those who relapsed during course of disease and those who did not. Median follow up was 15 months. [18F]FDG-PET/CT was analyzed for visual (PET vascular activity score [VAS]) and quantitative parameters, including Target-to-background-Ratio with liver (TBRliver) and jugular vein (TBRjv) serving as reference tissues. In addition, clinical parameters were tested.RESULTS:
8/21 (38.1â%) had relapse. Clinical parameters could not significantly discriminate between relapse vs no-relapse, including age (pâ=â0.9) or blood-based inflammatory markers (white blood cell counts [WBC] and c-reactive protein [CRP], pâ=â0.72, each). PETVAS score could also not differentiate between respective subgroups (pâ=â0.59). In a quantitative assessment, TBRjv demonstrated a trend towards significance (pâ=â0.28). TBRliver, however, separated between patients with and without relapse (pâ=â0.03).CONCLUSION:
[18F]FDG PET quantification of vessels may be useful to identify GCA patients prone to relapse during follow-up.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Giant Cell Arteritis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Nuklearmedizin
Year:
2023
Type:
Article
Affiliation country:
Germany