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Resuscitation, survival and morbidity of extremely preterm infants in California 2011-2019.
Higgins, Brennan V; Baer, Rebecca J; Steurer, Martina A; Karvonen, Kayla L; Oltman, Scott P; Jelliffe-Pawlowski, Laura L; Rogers, Elizabeth E.
Affiliation
  • Higgins BV; Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Brennan.higgins@ucsf.edu.
  • Baer RJ; California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
  • Steurer MA; Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
  • Karvonen KL; Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
  • Oltman SP; California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
  • Jelliffe-Pawlowski LL; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
  • Rogers EE; Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
J Perinatol ; 44(2): 209-216, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37689808
ABSTRACT

OBJECTIVE:

To describe changes over time in resuscitation, survival, and morbidity of extremely preterm infants in California. STUDY

DESIGN:

This population-based, retrospective cohort study includes infants born ≤28 weeks. Linked birth certificates and hospital discharge records were used to evaluate active resuscitation, survival, and morbidity across two epochs (2011-2014, 2015-2019).

RESULTS:

Of liveborn infants, 0.6% were born ≤28 weeks. Active resuscitation increased from 16.9% of 22-week infants to 98.1% of 25-week infants and increased over time in 22-, 23-, and 25-week infants (p-value ≤ 0.01). Among resuscitated infants, survival to discharge increased from 33.2% at 22 weeks to 96.1% at 28 weeks. Survival without major morbidity improved over time for 28-week infants (p-value < 0.01).

CONCLUSION:

Among infants ≤28 weeks, resuscitation and survival increased with gestational age and morbidity decreased. Over time, active resuscitation of periviable infants and morbidity-free survival of 28-week infants increased. These trends may inform counseling around extremely preterm birth.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Premature Birth / Infant, Premature, Diseases Type of study: Observational_studies Limits: Female / Humans / Infant / Newborn Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2024 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Premature Birth / Infant, Premature, Diseases Type of study: Observational_studies Limits: Female / Humans / Infant / Newborn Language: En Journal: J Perinatol Journal subject: PERINATOLOGIA Year: 2024 Type: Article Affiliation country: United States