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PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
Baldrighi, Marta; Doreth, Christian; Li, Yang; Zhao, Xiaohui; Warner, Emily; Chenoweth, Hannah; Kishore, Kamal; Umrania, Yagnesh; Minde, David-Paul; Thome, Sarah; Yu, Xian; Lu, Yuning; Knapton, Alice; Harrison, James; Clarke, Murray; Latz, Eicke; de Cárcer, Guillermo; Malumbres, Marcos; Ryffel, Bernhard; Bryant, Clare; Liu, Jinping; Lilley, Kathryn S; Mallat, Ziad; Li, Xuan.
Affiliation
  • Baldrighi M; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Doreth C; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Li Y; Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhao X; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Warner E; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Chenoweth H; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Kishore K; Cancer Research UK Cambridge Centre and.
  • Umrania Y; Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.
  • Minde DP; Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.
  • Thome S; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Yu X; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Lu Y; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Knapton A; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Harrison J; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Clarke M; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Latz E; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.
  • de Cárcer G; Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Malumbres M; Cell Cycle and Cancer Biomarkers Group, "Alberto Sols" Biomedical Research Institute (IIBM-CSIC), Madrid, Spain.
  • Ryffel B; Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Bryant C; UMR7355 INEM, Experimental and Molecular Immunology and Neurogenetics CNRS and Université d'Orleans, Orleans, France.
  • Liu J; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Lilley KS; Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Mallat Z; Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.
  • Li X; The Victor Phillip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
J Clin Invest ; 133(21)2023 11 01.
Article in En | MEDLINE | ID: mdl-37698938
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Animals Language: En Journal: J Clin Invest Year: 2023 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Animals Language: En Journal: J Clin Invest Year: 2023 Type: Article Affiliation country: United kingdom