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Anti-GM-CSF otilimab versus tofacitinib or placebo in patients with active rheumatoid arthritis and an inadequate response to conventional or biologic DMARDs: two phase 3 randomised trials (contRAst 1 and contRAst 2).
Fleischmann, Roy M; van der Heijde, Désirée; Strand, Vibeke; Atsumi, Tatsuya; McInnes, Iain B; Takeuchi, Tsutomu; Taylor, Peter C; Bracher, Marguerite; Brooks, David; Davies, John; Goode, Christopher; Gupta, Anubha; Mukherjee, Sumanta; O'Shea, Ciara; Saurigny, Didier; Schifano, Lorrie A; Shelton, Celia; Smith, Julia E; Wang, Millie; Wang, Reena; Watts, Sarah; Weinblatt, Michael E.
Affiliation
  • Fleischmann RM; Department of Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA rfleischmann@arthdocs.com.
  • van der Heijde D; Metroplex Clinical Research Center, Dallas, Texas, USA.
  • Strand V; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
  • Atsumi T; Division of Immunology/Rheumatology, Stanford University, Palo Alto, California, USA.
  • McInnes IB; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Takeuchi T; College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • Taylor PC; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine Graduate School of Medicine, Shinjuku-ku, Japan.
  • Bracher M; Saitama Medical University, Saitama, Japan.
  • Brooks D; Botnar Research Centre, University of Oxford, Oxford, UK.
  • Davies J; GSK, Stevenage, UK.
  • Goode C; GSK, Collegeville, Pennsylvania, USA.
  • Gupta A; GSK, Stevenage, UK.
  • Mukherjee S; GSK, Brentford, UK.
  • O'Shea C; GSK, Stevenage, UK.
  • Saurigny D; GSK, Collegeville, Pennsylvania, USA.
  • Schifano LA; GSK, Dublin, Ireland.
  • Shelton C; GSK, Stevenage, UK.
  • Smith JE; GSK, Durham, North Carolina, USA.
  • Wang M; GSK, Collegeville, Pennsylvania, USA.
  • Wang R; GSK, Stevenage, UK.
  • Watts S; GSK, Brentford, UK.
  • Weinblatt ME; GSK, Collegeville, Pennsylvania, USA.
Ann Rheum Dis ; 82(12): 1516-1526, 2023 12.
Article in En | MEDLINE | ID: mdl-37699654
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Biological Products / Antirheumatic Agents Type of study: Clinical_trials Limits: Humans Language: En Journal: Ann Rheum Dis Year: 2023 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Biological Products / Antirheumatic Agents Type of study: Clinical_trials Limits: Humans Language: En Journal: Ann Rheum Dis Year: 2023 Type: Article Affiliation country: United States