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A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023.
Takashita, Emi; Fujisaki, Seiichiro; Morita, Hiroko; Nagata, Shiho; Miura, Hideka; Matsuura, Yuki; Yamamoto, Saya; Chiba, Shoko; Inoue, Yumiko; Minami, Iori; Yoshikawa, Sayaka; Yamazaki, Seiko; Kishida, Noriko; Nakamura, Kazuya; Shirakura, Masayuki; Watanabe, Shinji; Hasegawa, Hideki.
Affiliation
  • Takashita E; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Fujisaki S; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Morita H; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Nagata S; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Miura H; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Matsuura Y; Nara Prefecture Institute of Health, Nara, Japan.
  • Yamamoto S; Nara Prefecture Institute of Health, Nara, Japan.
  • Chiba S; Nara Prefecture Institute of Health, Nara, Japan.
  • Inoue Y; Nara Prefecture Institute of Health, Nara, Japan.
  • Minami I; Nara Prefecture Institute of Health, Nara, Japan.
  • Yoshikawa S; Nara Prefecture Institute of Health, Nara, Japan.
  • Yamazaki S; Nara Prefecture Institute of Health, Nara, Japan.
  • Kishida N; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Nakamura K; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Shirakura M; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Watanabe S; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
  • Hasegawa H; Research Centre for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
Euro Surveill ; 28(39)2023 09.
Article in En | MEDLINE | ID: mdl-37768560
ABSTRACT
A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiepins / Influenza, Human Limits: Humans Country/Region as subject: Asia Language: En Journal: Euro Surveill Journal subject: DOENCAS TRANSMISSIVEIS Year: 2023 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiepins / Influenza, Human Limits: Humans Country/Region as subject: Asia Language: En Journal: Euro Surveill Journal subject: DOENCAS TRANSMISSIVEIS Year: 2023 Type: Article Affiliation country: Japan