A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023.
Euro Surveill
; 28(39)2023 09.
Article
in En
| MEDLINE
| ID: mdl-37768560
ABSTRACT
A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiepins
/
Influenza, Human
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Euro Surveill
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2023
Type:
Article
Affiliation country:
Japan