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Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
Yuan, Yukun; Lopez-Santiago, Luis; Denomme, Nicholas; Chen, Chunling; O'Malley, Heather A; Hodges, Samantha L; Ji, Sophina; Han, Zhou; Christiansen, Anne; Isom, Lori L.
Affiliation
  • Yuan Y; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lopez-Santiago L; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Denomme N; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Chen C; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • O'Malley HA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Hodges SL; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Ji S; Stoke Therapeutics, Inc., Bedford, MA 01730, USA.
  • Han Z; Stoke Therapeutics, Inc., Bedford, MA 01730, USA.
  • Christiansen A; Stoke Therapeutics, Inc., Bedford, MA 01730, USA.
  • Isom LL; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Brain ; 147(4): 1231-1246, 2024 Apr 04.
Article in En | MEDLINE | ID: mdl-37812817
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Epilepsies, Myoclonic Limits: Animals / Humans Language: En Journal: Brain Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides, Antisense / Epilepsies, Myoclonic Limits: Animals / Humans Language: En Journal: Brain Year: 2024 Type: Article Affiliation country: United States