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Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
Specker, Edgar; Wesolowski, Radoslaw; Schütz, Anja; Matthes, Susann; Mallow, Keven; Wasinska-Kalwa, Malgorzata; Winkler, Lars; Oder, Andreas; Alenina, Natalia; Pleimes, Dirk; von Kries, Jens Peter; Heinemann, Udo; Bader, Michael; Nazaré, Marc.
Affiliation
  • Specker E; Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Wesolowski R; Trypto Therapeutics GmbH, Robert-Rössle Straße 10, 13125 Berlin, Germany.
  • Schütz A; Trypto Therapeutics GmbH, Robert-Rössle Straße 10, 13125 Berlin, Germany.
  • Matthes S; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Mallow K; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Wasinska-Kalwa M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Winkler L; Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Oder A; Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Alenina N; Experimental Pharmacology and Oncology GmbH, Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Pleimes D; Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • von Kries JP; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
  • Heinemann U; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Potsdamer Straße 58, 10785 Berlin, Germany.
  • Bader M; Trypto Therapeutics GmbH, Robert-Rössle Straße 10, 13125 Berlin, Germany.
  • Nazaré M; Chemical Biology Platform, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin-Buch, Germany.
J Med Chem ; 66(21): 14866-14896, 2023 11 09.
Article in En | MEDLINE | ID: mdl-37905925
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Tryptophan Hydroxylase Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Tryptophan Hydroxylase Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: Germany