EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells.

Kim, Seung J; Kiser, Patti K; Asfaha, Samuel; DeKoter, Rodney P; Dick, Frederick A

Kim, Seung J; Kiser, Patti K; Asfaha, Samuel; DeKoter, Rodney P; Dick, Frederick A.

Affiliation

Kim SJ; London Regional Cancer Program, Children's Health Research Institute, London, ON, Canada.
Kiser PK; London Health Sciences Research Institute, London, ON, Canada.
Asfaha S; Department of Biochemistry, Western University, London, ON, Canada.
DeKoter RP; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.
Dick FA; London Regional Cancer Program, Children's Health Research Institute, London, ON, Canada.

EMBO J ; 42(24): e114462, 2023 Dec 11.

Article in En | MEDLINE | ID: mdl-37934086

Subject(s)

B-Lymphocytes; Enhancer of Zeste Homolog 2 Protein; Epstein-Barr Virus Infections; Animals; Mice; B-Lymphocytes/drug effects; B-Lymphocytes/metabolism; DNA Methylation; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors; Enhancer of Zeste Homolog 2 Protein/genetics; Enhancer of Zeste Homolog 2 Protein/metabolism; Epstein-Barr Virus Infections/genetics; Herpesvirus 4, Human/genetics; Histones/metabolism; Repetitive Sequences, Nucleic Acid

Key words

autoimmunity; heterochromatin; inflammation; therapeutic; virus

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Epstein-Barr Virus Infections / Enhancer of Zeste Homolog 2 Protein Limits: Animals Language: En Journal: EMBO J Year: 2023 Type: Article Affiliation country: Canada

Fulltext

XML

PubMed Links

Search on Google