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Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions.
Iorgu, Ana-Maria; Vasilescu, Andrei-Nicolae; Pfeiffer, Natascha; Spanagel, Rainer; Mallien, Anne Stephanie; Inta, Dragos; Gass, Peter.
Affiliation
  • Iorgu AM; Department of Psychiatry and Psychotherapy, Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany. ana-maria.iorgu@uni-heidelberg.de.
  • Vasilescu AN; Department of Psychiatry and Psychotherapy, Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany.
  • Pfeiffer N; Department of Psychiatry and Psychotherapy, Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany.
  • Spanagel R; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Mallien AS; Department of Psychiatry and Psychotherapy, Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany.
  • Inta D; Department for Community Health, Faculty of Natural Sciences and Medicine, University of Fribourg, Fribourg, Switzerland.
  • Gass P; Department of Biomedicine, University of Basel, Basel, Switzerland.
Eur Arch Psychiatry Clin Neurosci ; 2023 Nov 07.
Article in En | MEDLINE | ID: mdl-37934233
ABSTRACT
S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney's lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Eur Arch Psychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2023 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Eur Arch Psychiatry Clin Neurosci Journal subject: NEUROLOGIA / PSIQUIATRIA Year: 2023 Type: Article Affiliation country: Germany