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Genetic diversity and microevolution in clinical Cryptococcus isolates from Cameroon.
Sephton-Clark, Poppy; Temfack, Elvis; Tenor, Jennifer L; Toffaletti, Dena L; Loyse, Angela; Molloy, Síle F; Perfect, John R; Bicanic, Tihana; Harrison, Thomas S; Lortholary, Olivier; Kouanfack, Charles; Cuomo, Christina A.
Affiliation
  • Sephton-Clark P; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Temfack E; Internal Medicine Unit, Douala General Hospital, Douala, Cameroon.
  • Tenor JL; Institut Pasteur, Molecular Mycology Unit, CNRS UMR 2000, Paris, France.
  • Toffaletti DL; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
  • Loyse A; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
  • Molloy SF; Institute of Infection and Immunity, St George's University of London, London, UK.
  • Perfect JR; Clinical Academic Group in Infection, St George's University Hospital, London, UK.
  • Bicanic T; Institute of Infection and Immunity, St George's University of London, London, UK.
  • Harrison TS; Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
  • Lortholary O; Institute of Infection and Immunity, St George's University of London, London, UK.
  • Kouanfack C; Clinical Academic Group in Infection, St George's University Hospital, London, UK.
  • Cuomo CA; Institute of Infection and Immunity, St George's University of London, London, UK.
Med Mycol ; 61(12)2023 Dec 01.
Article in En | MEDLINE | ID: mdl-37952096
Cryptococcal meningitis, caused by Cryptococcus, results in approximately half a million deaths per year globally. We compare clinical Cryptococcus samples from Cameroon and Malawi to explore the genetic diversity of these isolates. We find instances of mixed-strain infections and identify genetic variants arising in Cryptococcus over disease.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Acquired Immunodeficiency Syndrome / Meningitis, Cryptococcal / Cryptococcus / Cryptococcus neoformans / Coinfection Limits: Humans Country/Region as subject: Africa Language: En Journal: Med Mycol Journal subject: MEDICINA VETERINARIA / MICROBIOLOGIA Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Acquired Immunodeficiency Syndrome / Meningitis, Cryptococcal / Cryptococcus / Cryptococcus neoformans / Coinfection Limits: Humans Country/Region as subject: Africa Language: En Journal: Med Mycol Journal subject: MEDICINA VETERINARIA / MICROBIOLOGIA Year: 2023 Type: Article Affiliation country: United States