Lipid Lowering Drugs in Acute Coronary Syndromes (ACS).
Curr Atheroscler Rep
; 25(12): 939-946, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-38015336
ABSTRACT
PURPOSE OF REVIEW The purpose of this review is to critically discuss whether more aggressive lipid-lowering strategies are needed in patients with acute coronary syndromes (ACS). RECENT FINDINGS:
Currently, available data on early (in-hospital/discharge) administration of potent lipid-lowering drugs, such as proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors in patients during the vulnerable post-ACS phase, have clearly demonstrated clinical efficacy of the "strike early and strike strong" approach not only for rapid reduction of low-density lipoprotein cholesterol (LDL-C) to unprecedentedly low levels, but also for associated favorable composition of coronary plaque. Intensive lipid-lowering therapy with rapid achievement of the LDL-C treatment goal in ACS patients seems reasonable. However, whether such profound LDL-C reduction would result in additional benefit on the reduction of future CV events still has to be established. Thus, data addressing CV outcomes in such vulnerable patients at extreme CV risk are urgently needed.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Acute Coronary Syndrome
/
Anticholesteremic Agents
Limits:
Humans
Language:
En
Journal:
Curr Atheroscler Rep
Journal subject:
ANGIOLOGIA
Year:
2023
Type:
Article
Affiliation country:
Germany