A flexible multi-metric Bayesian framework for decision-making in Phase II multi-arm multi-stage studies.

Dufault, Suzanne M; Crook, Angela M; Rolfe, Katie; Phillips, Patrick P J

Dufault, Suzanne M; Crook, Angela M; Rolfe, Katie; Phillips, Patrick P J.

Affiliation

Dufault SM; Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Crook AM; UCSF Center for Tuberculosis, University of California, San Francisco, CA, USA.
Rolfe K; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, London, UK.
Phillips PPJ; GSK, Stevenage, UK.

Stat Med ; 43(3): 501-513, 2024 02 10.

Article in En | MEDLINE | ID: mdl-38038137

Subject(s)

Research Design; Humans; Bayes Theorem; Sample Size; Uncertainty; Computer Simulation

Key words

Bayesian methods; interim analysis; multi-arm multi-stage; phase II; time to positivity; tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Research Design Limits: Humans Language: En Journal: Stat Med Year: 2024 Type: Article Affiliation country: United States

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