Tape strips detect molecular alterations and cutaneous biomarkers in skin of patients with hidradenitis suppurativa.
J Am Acad Dermatol
; 90(4): 749-758, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38049071
ABSTRACT
BACKGROUND:
Hidradenitis suppurativa (HS) has a high unmet need for better treatments. Biopsies are considered the gold standard for studying molecular alterations in skin. A reproducible, minimally invasive approach is needed for longitudinal monitoring in trials and in pediatric populations.OBJECTIVE:
To determine whether skin tape strips can detect molecular alterations in HS and identify biomarkers of disease activity.METHODS:
We performed RNA sequencing on tape strips collected from lesional and healthy-appearing (nonlesional) HS skin (n = 22) and healthy controls (n = 21). We correlated the expression of skin biomarkers between tape strips and a previously published gene-signature of HS biopsies.RESULTS:
Tape strips detected upregulation of known HS biomarkers (eg, Interleukin[IL]-17A) in nonlesional and/or lesional skin and also identified novel clinically actionable targets, including OX40 and JAK3. The expression of Th17 and tumor necrosis factor-α pathways were highly correlated between tape strips and biopsies. HS clinical severity was significantly associated with expression of biomarkers (eg tumor necrosis factor-α , IL-17 A/F, OX40, JAK1-3, IL-4R) in HS lesional and/or nonlesional skin.LIMITATIONS:
Sample size. Tape stripping is limited in depth.CONCLUSION:
This study validates tape strips as a minimally-invasive approach to identify cutaneous biomarkers in HS. This provides a novel avenue for monitoring treatment efficacy and a potential step toward individualized therapy in HS.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hidradenitis Suppurativa
Limits:
Child
/
Humans
Language:
En
Journal:
J Am Acad Dermatol
Year:
2024
Type:
Article