RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
Med
; 4(12): 863-874, 2023 Dec 08.
Article
in En
| MEDLINE
| ID: mdl-38070481
ABSTRACT
Emerging evidence suggests that local tumor radiotherapy reshapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microenvironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA m6A modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenvironment. We discuss potential therapeutic interventions targeting m6A machinery to improve radiotherapy response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myeloid-Derived Suppressor Cells
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Med
Year:
2023
Type:
Article