4-Octyl itaconate alleviates experimental autoimmune prostatitis by inhibiting the NLRP3 inflammasome-induced pyroptosis through activating Nrf2/HO-1 pathway.

Zhao, Xiaohu; Feng, Rui; Chen, Juan; Jiang, Qing; Hua, Xiaoliang; Liang, Chaozhao

Zhao, Xiaohu; Feng, Rui; Chen, Juan; Jiang, Qing; Hua, Xiaoliang; Liang, Chaozhao.

Affiliation

Zhao X; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Feng R; Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen J; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jiang Q; Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hua X; The Ministry of Education Key Laboratory of Laboratory Medical Diagnostics, The College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Liang C; Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Prostate ; 84(4): 329-341, 2024 Mar.

Article in En | MEDLINE | ID: mdl-38073004

Subject(s)

Diabetes Mellitus, Experimental; Prostatitis; Succinates; Humans; Male; Mice; Animals; Middle Aged; Prostatitis/drug therapy; Inflammasomes; NF-E2-Related Factor 2/therapeutic use; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Chronic Disease; Inflammation; Anti-Inflammatory Agents/therapeutic use; Superoxide Dismutase/therapeutic use

Key words

4-Octyl itaconate; chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS); inflammation; pyroptosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatitis / Succinates / Diabetes Mellitus, Experimental Limits: Animals / Humans / Male / Middle aged Language: En Journal: Prostate Year: 2024 Type: Article Affiliation country: China

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