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Cytotoxic withanolides from the leaves of Datura stramonium L.
Pan, Juan; Liu, Yan; Li, Xin-Yuan; Wang, Si-Yi; Wu, Jia-Tong; Li, Meng-Meng; Guan, Wei; Mohammed Algradi, Adnan; Kuang, Hai-Xue; Yang, Bing-You.
Affiliation
  • Pan J; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Liu Y; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Li XY; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Wang SY; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Wu JT; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Li MM; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Guan W; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Mohammed Algradi A; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Kuang HX; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
  • Yang BY; Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, China.
Chem Biodivers ; 21(2): e202301655, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38084071
ABSTRACT
Six novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanlides demonstrated interesting cytotoxic activity on LN229 cells with IC50 <20 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Datura stramonium / Withanolides / Antineoplastic Agents Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Datura stramonium / Withanolides / Antineoplastic Agents Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Type: Article Affiliation country: China