BPA induces hepatotoxicity in zebrafish through oxidative stress and apoptosis pathways.
Fish Physiol Biochem
; 50(2): 403-412, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38085449
ABSTRACT
BPA is so ubiquitous that 27 million tons of BPA-containing plastic, including mineral water bottles and baby bottles, is produced worldwide each year. The potential toxicity of BPA to humans and aquatic organisms has been the subject of intense research. In this study, a zebrafish model system was used to assess BPA-mediated hepatotoxicity. Zebrafish larvae at 72-144 hpf were exposed to BPA at different concentrations (0,1, 3 and 5mg/L). For example, BPA-treated zebrafish larvae showed increased mortality, delayed uptake of nutrients in yolk sac, shortened body length, smaller liver area, abnormal expression of genes related to liver development, and pathological changes in the liver tissue. Mechanistically, BPA exposure induced excessive oxidative stress in the liver of zebrafish and increased the level of hepatocyte apoptosis in zebrafish larvae, and the antioxidant astaxanthin could rescue the BPA-mediated liver toxicity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Water Pollutants, Chemical
/
Chemical and Drug Induced Liver Injury
Limits:
Animals
/
Humans
Language:
En
Journal:
Fish Physiol Biochem
Year:
2024
Type:
Article
Affiliation country:
China