Changes in Adiposity and Cognitive Function in Older Adults: The REGARDS Study.
J Gerontol B Psychol Sci Soc Sci
; 79(3)2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38134240
ABSTRACT
OBJECTIVES:
Adiposity may have a role in the risk of dementia. Fewer studies have focused on the relationship between change in adiposity and cognitive decline. Our study aimed to explore the association between the change in adiposity and cognitive function in Black and White older adults.METHODS:
The participants were 12,204 older adults without cognitive impairment (62.8â ±â 8.0 years) in the United States. The percent body mass index change (%BMI change) and percent waist circumference change (%WC change) were measured at 2 in-home visits (first 2003-2007, second 2013-2016). Cognitive status was assessed by the Six-Item Screener annually. Memory and executive function were measured by word list learning, MOCA recall and orientation, and letter and animal fluency every 2 years. Logistic regression or linear regression models were used to estimate the relationship between percent change in adiposity and cognitive function.RESULTS:
After 12.7â ±â 1.7 years, a greater decrease in %BMI change or %WC change was significantly associated with a higher risk of cognitive impairment. Compared to older adults with -5% ≤ changeâ ≤â 5% from baseline, a significantly higher risk of cognitive impairment and greater loss in memory and executive function were found among those who experienced more than a 10% decline in %BMI change or %WC change. Older adults who experienced a 5%-10% decrease in %BMI change had a higher risk of cognitive impairment and greater loss of memory compared to those with -5%â ≤â changeâ ≤â 5%.DISCUSSION:
A greater decrease in %BMI (>5%) and %WC (>10%) change was associated with greater cognitive loss observed over time.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cognition Disorders
/
Cognitive Dysfunction
Limits:
Aged
/
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
J Gerontol B Psychol Sci Soc Sci
Journal subject:
CIENCIAS SOCIAIS
/
GERIATRIA
/
PSICOLOGIA
Year:
2024
Type:
Article
Affiliation country:
China