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Experimental Modeling of Host-Bacterial Interactions in Head and Neck Squamous Cell Carcinoma.
Okolo, Ogoegbunam; Honzel, Emily; Britton, William R; Yu, Victoria X; Flashner, Samuel; Martin, Cecilia; Nakagawa, Hiroshi; Parikh, Anuraag S.
Affiliation
  • Okolo O; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.
  • Honzel E; Columbia Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
  • Britton WR; Columbia Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
  • Yu VX; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.
  • Flashner S; Columbia Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
  • Martin C; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.
  • Nakagawa H; Department of Otolaryngology-Head and Neck Surgery, Columbia University, New York, NY 10027, USA.
  • Parikh AS; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA.
Cancers (Basel) ; 15(24)2023 Dec 12.
Article in En | MEDLINE | ID: mdl-38136355
ABSTRACT
The microscopic species colonizing the human body, collectively referred to as the microbiome, play a crucial role in the maintenance of tissue homeostasis, immunity, and the development of disease. There is evidence to suggest associations between alterations in the microbiome and the development of head and neck squamous cell carcinomas (HNSCC). The use of two-dimensional (2D) modeling systems has made significant strides in uncovering the role of microbes in carcinogenesis; however, direct mechanistic links remain in their infancy. Patient-derived three-dimensional (3D) HNSCC organoid and organotypic models have recently been described. Compared to 2D models, 3D organoid culture systems effectively capture the genetic and epigenetic features of parent tissue in a patient-specific manner and may offer a more nuanced understanding of the role of host-microbe responses in carcinogenesis. This review provides a topical literature review assessing the current state of the field investigating the role of the microbiome in HNSCC; including in vivo and in vitro modeling methods that may be used to characterize microbiome-epithelial interactions.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cancers (Basel) Year: 2023 Type: Article Affiliation country: United States