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High-resolution myelin-water fraction and quantitative relaxation mapping using 3D ViSTa-MR fingerprinting.
Liao, Congyu; Cao, Xiaozhi; Iyer, Siddharth Srinivasan; Schauman, Sophie; Zhou, Zihan; Yan, Xiaoqian; Chen, Quan; Li, Zhitao; Wang, Nan; Gong, Ting; Wu, Zhe; He, Hongjian; Zhong, Jianhui; Yang, Yang; Kerr, Adam; Grill-Spector, Kalanit; Setsompop, Kawin.
Affiliation
  • Liao C; Department of Radiology, Stanford University, Stanford, California, USA.
  • Cao X; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
  • Iyer SS; Department of Radiology, Stanford University, Stanford, California, USA.
  • Schauman S; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
  • Zhou Z; Department of Radiology, Stanford University, Stanford, California, USA.
  • Yan X; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Chen Q; Department of Radiology, Stanford University, Stanford, California, USA.
  • Li Z; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
  • Wang N; Department of Radiology, Stanford University, Stanford, California, USA.
  • Gong T; Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
  • Wu Z; Department of Psychology, Stanford University, Stanford, California, USA.
  • He H; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
  • Zhong J; Department of Radiology, Stanford University, Stanford, California, USA.
  • Yang Y; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
  • Kerr A; Department of Radiology, Stanford University, Stanford, California, USA.
  • Grill-Spector K; Department of Radiology, Stanford University, Stanford, California, USA.
  • Setsompop K; Department of Electrical Engineering, Stanford University, Stanford, California, USA.
Magn Reson Med ; 91(6): 2278-2293, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38156945
ABSTRACT

PURPOSE:

This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan time.

METHODS:

We developed 3D visualization of short transverse relaxation time component (ViSTa)-MRF, which combined ViSTa technique with MR fingerprinting (MRF), to achieve high-fidelity whole-brain MWF and T1/T2/PD mapping on a clinical 3T scanner. To achieve fast acquisition and memory-efficient reconstruction, the ViSTa-MRF sequence leverages an optimized 3D tiny-golden-angle-shuffling spiral-projection acquisition and joint spatial-temporal subspace reconstruction with optimized preconditioning algorithm. With the proposed ViSTa-MRF approach, high-fidelity direct MWF mapping was achieved without a need for multicompartment fitting that could introduce bias and/or noise from additional assumptions or priors.

RESULTS:

The in vivo results demonstrate the effectiveness of the proposed acquisition and reconstruction framework to provide fast multi-parametric mapping with high SNR and good quality. The in vivo results of 1 mm- and 0.66 mm-isotropic resolution datasets indicate that the MWF values measured by the proposed method are consistent with standard ViSTa results that are 30× slower with lower SNR. Furthermore, we applied the proposed method to enable 5-min whole-brain 1 mm-iso assessment of MWF and T1/T2/PD mappings for infant brain development and for post-mortem brain samples.

CONCLUSIONS:

In this work, we have developed a 3D ViSTa-MRF technique that enables the acquisition of whole-brain MWF, quantitative T1, T2, and PD maps at 1 and 0.66 mm isotropic resolution in 5 and 15 min, respectively. This advancement allows for quantitative investigations of myelination changes in the brain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Myelin Sheath Limits: Humans Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Myelin Sheath Limits: Humans Language: En Journal: Magn Reson Med Journal subject: DIAGNOSTICO POR IMAGEM Year: 2024 Type: Article Affiliation country: United States