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Microbial transmission in the social microbiome and host health and disease.
Sarkar, Amar; McInroy, Cameron J A; Harty, Siobhán; Raulo, Aura; Ibata, Neil G O; Valles-Colomer, Mireia; Johnson, Katerina V-A; Brito, Ilana L; Henrich, Joseph; Archie, Elizabeth A; Barreiro, Luis B; Gazzaniga, Francesca S; Finlay, B Brett; Koonin, Eugene V; Carmody, Rachel N; Moeller, Andrew H.
Affiliation
  • Sarkar A; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. Electronic address: amarsarkar@g.harvard.edu.
  • McInroy CJA; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  • Harty S; Independent, Tandy Court, Spitalfields, Dublin, Ireland.
  • Raulo A; Department of Biology, University of Oxford, Oxford, UK; Department of Computing, University of Turku, Turku, Finland.
  • Ibata NGO; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  • Valles-Colomer M; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
  • Johnson KV; Institute of Psychology, Leiden University, Leiden, the Netherlands; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Brito IL; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
  • Henrich J; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  • Archie EA; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
  • Barreiro LB; Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.
  • Gazzaniga FS; Molecular Pathology Unit, Cancer Center, Massachusetts General Hospital Research Institute, Charlestown, MA, USA; Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • Finlay BB; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada; Department of Biochemistry, University of British Columbia, Vancouver, BC, Canada.
  • Koonin EV; National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA.
  • Carmody RN; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
  • Moeller AH; Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USA.
Cell ; 187(1): 17-43, 2024 01 04.
Article in En | MEDLINE | ID: mdl-38181740
ABSTRACT
Although social interactions are known to drive pathogen transmission, the contributions of socially transmissible host-associated mutualists and commensals to host health and disease remain poorly explored. We use the concept of the social microbiome-the microbial metacommunity of a social network of hosts-to analyze the implications of social microbial transmission for host health and disease. We investigate the contributions of socially transmissible microbes to both eco-evolutionary microbiome community processes (colonization resistance, the evolution of virulence, and reactions to ecological disturbance) and microbial transmission-based processes (transmission of microbes with metabolic and immune effects, inter-specific transmission, transmission of antibiotic-resistant microbes, and transmission of viruses). We consider the implications of social microbial transmission for communicable and non-communicable diseases and evaluate the importance of a socially transmissible component underlying canonically non-communicable diseases. The social transmission of mutualists and commensals may play a significant, under-appreciated role in the social determinants of health and may act as a hidden force in social evolution.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Symbiosis / Microbiota / Social Factors Limits: Animals / Humans Language: En Journal: Cell Year: 2024 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Symbiosis / Microbiota / Social Factors Limits: Animals / Humans Language: En Journal: Cell Year: 2024 Type: Article