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Exploiting the beneficial effects of Salvia officinalis L. extracts in human health and assessing their activity as potent functional regulators of food microbiota.
Kompoura, Vasiliki; Karapantzou, Ioanna; Mitropoulou, Gregoria; Parisis, Nikolaos A; Gkalpinos, Vasileios K; Anagnostou, Vasiliki A; Tsiailanis, Antonis D; Vasdekis, Efstathios P; Koutsaliaris, Ioannis K; Tsouka, Aikaterini N; Karapetsi, Lefkothea; Madesis, Panagiotis; Letsiou, Stavroula; Florou, Dimitra; Koukkou, Anna-Irini; Barbouti, Alexandra; Tselepis, Alexandros D; Kourkoutas, Yiannis; Tzakos, Andreas G.
Affiliation
  • Kompoura V; Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
  • Karapantzou I; Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
  • Mitropoulou G; Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
  • Parisis NA; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Gkalpinos VK; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Anagnostou VA; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Tsiailanis AD; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Vasdekis EP; Directorate of Rural Economy, Region of Epirus, Ioannina, Greece.
  • Koutsaliaris IK; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Tsouka AN; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Karapetsi L; Laboratory of Molecular Biology of Plants, Department of Agriculture Crop Production and Rural Environment, University of Thessaly, Fytokou St., N. Ionia, 38446 Magnesia, Greece; Institute of Applied Biosciences (INAB), Centre for Research and Technology Hellas (CERTH), 6th Km Charilaou-Thermi Road,
  • Madesis P; Laboratory of Molecular Biology of Plants, Department of Agriculture Crop Production and Rural Environment, University of Thessaly, Fytokou St., N. Ionia, 38446 Magnesia, Greece; Institute of Applied Biosciences (INAB), Centre for Research and Technology Hellas (CERTH), 6th Km Charilaou-Thermi Road,
  • Letsiou S; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Florou D; Department of Forensic Medicine & Toxicology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
  • Koukkou AI; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.
  • Barbouti A; Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
  • Tselepis AD; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
  • Kourkoutas Y; Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
  • Tzakos AG; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; University Research Center of Ioannina, Institute of Materials Science and Computing, Ioannina, Greece. Electronic address: atzakos@uoi.gr.
Food Chem ; 441: 138175, 2024 May 30.
Article in En | MEDLINE | ID: mdl-38194793
ABSTRACT
Salvia officinalis L. has attracted scientific and industrial interest due to its pharmacological properties. However, its detailed phytochemical profile and its correlation with beneficial effects in the human microbiome and oxidative stress remained elusive. To unveil this, S. officinalis was collected from the region of Epirus and its molecular identity was verified with DNA barcoding. Phytochemical profile for both aqueous and ethanol-based extracts was determined by high-pressure liquid chromatography-tandem mass spectrometry and 103 phytochemicals were determined. The effect of S. officinalis extracts as functional regulators of food microbiota by stimulating the growth of Lacticaseibacillus rhamnosus strains and by suppressing evolution of pathogenic bacteria was verified. Furthermore, we recorded that both extracts exhibited a significant cellular protection against H2O2-induced DNA damage. Finally, both extracts exhibited strong inhibitory effect towards LDL oxidation. This study provides a comprehensive characterization of S. officinalis on its phytochemical components as also its potential impact in human microbiome and oxidative stress.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salvia officinalis Limits: Humans Language: En Journal: Food Chem Year: 2024 Type: Article Affiliation country: Greece
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salvia officinalis Limits: Humans Language: En Journal: Food Chem Year: 2024 Type: Article Affiliation country: Greece