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Methylation of the Vitamin D Receptor Gene in Human Disorders.
Gasperini, Beatrice; Falvino, Angela; Piccirilli, Eleonora; Tarantino, Umberto; Botta, Annalisa; Visconti, Virginia Veronica.
Affiliation
  • Gasperini B; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
  • Falvino A; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
  • Piccirilli E; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
  • Tarantino U; Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
  • Botta A; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
  • Visconti VV; Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Int J Mol Sci ; 25(1)2023 Dec 20.
Article in En | MEDLINE | ID: mdl-38203278
ABSTRACT
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Receptors, Calcitriol Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / Receptors, Calcitriol Limits: Humans Language: En Journal: Int J Mol Sci Year: 2023 Type: Article Affiliation country: Italy