Your browser doesn't support javascript.
loading
TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
Li, Xuan; You, Jieyun; Dai, Fangjie; Wang, Shijun; Yang, Feng Hua; Wang, Xingxu; Ding, Zhiwen; Huang, Jiayuan; Chen, Liming; Abudureyimu, Miyesaier; Tang, Haiyang; Yang, Xiangdong; Xiang, Yaozu; Backx, Peter H; Ren, Jun; Ge, Junbo; Zou, Yunzeng; Wu, Jian.
Affiliation
  • Li X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • You J; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Dai F; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Wang S; Department of Cardiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  • Yang FH; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Wang X; Guangdong Laboratory Animals Monitoring Institute, Guangdong Province Key Laboratory of Laboratory Animals, Guangzhou, China.
  • Ding Z; Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Huang J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Chen L; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Abudureyimu M; Guangdong Laboratory Animals Monitoring Institute, Guangdong Province Key Laboratory of Laboratory Animals, Guangzhou, China.
  • Tang H; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Yang X; Cardiovascular Department, Shanghai Xuhui Central Hospital, Fudan University, Shanghai, China.
  • Xiang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China.
  • Backx PH; Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Ren J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
  • Ge J; Shanghai East Hospital, Key Laboratory of Arrhythmias of the Ministry of Education of China, School of Life Sciences and Technology, Tongji University, Shanghai, China.
  • Zou Y; Department of Biology, Faculty of Science, York University, Toronto, Ontario, Canada.
  • Wu J; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
JACC Basic Transl Sci ; 8(12): 1555-1573, 2023 Dec.
Article in En | MEDLINE | ID: mdl-38205342
ABSTRACT
A comprehensive view of the role of NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented in this study. Furthermore, mitigation of NLRP3 deficiency-induced pyroptosis confers cardioprotection against pressure overload through activation of TAK1, whereas this salutary effect is abolished by inhibition of TAK1 activity, highlighting a previously unrecognized reciprocally regulatory role of NLRP3-TAK1 governing inflammation-induced cell death and hypertrophic growth. Translationally, this study advocates strategies based on inflammation-induced cell death might be exploited therapeutically in other inflammatory and mechanical overload disorders, such as myocardial infarction and mitral regurgitation.
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2023 Type: Article Affiliation country: China
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2023 Type: Article Affiliation country: China