Progress and Implications from Genetic Studies of Bipolar Disorder.
Neurosci Bull
; 40(8): 1160-1172, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38206551
ABSTRACT
With the advancements in gene sequencing technologies, including genome-wide association studies, polygenetic risk scores, and high-throughput sequencing, there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder (BD). To date, intriguing genetic clues have been identified to explain the development of BD, as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic intervention. Risk genes of BD, such as CACNA1C, ANK3, TRANK1, and CLOCK, have been found to be involved in various pathophysiological processes correlated with BD. Although the specific roles of these genes have yet to be determined, genetic research on BD will help improve the prevention, therapeutics, and prognosis in clinical practice. The latest preclinical and clinical studies, and reviews of the genetics of BD, are analyzed in this review, aiming to summarize the progress in this intriguing field and to provide perspectives for individualized, precise, and effective clinical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Genetic Predisposition to Disease
/
Genome-Wide Association Study
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Bull
Journal subject:
NEUROLOGIA
Year:
2024
Type:
Article
Affiliation country:
China