Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs.
BMC Immunol
; 25(1): 7, 2024 01 16.
Article
in En
| MEDLINE
| ID: mdl-38229027
ABSTRACT
BACKGROUND:
Biomarkers that can predict outcome will improve the efficacy of treatment for HNSCC patients. In this regard, we retrospectively evaluated the prognostic effect of PD1, PD-L1, and CD45RO in tongue and larynx squamous cell carcinomas.METHODS:
FFPE tissue blocks of 63 larynx and 40 tongue squamous cell carcinoma samples were selected, cut into 3 µm sections, and immunohistochemically stained for PD1, PD-L1, and CD45RO. The slides were evaluated by an expert pathologist, and results were analysed using Chi-square, univariate, and multivariable Cox regression methods.RESULTS:
TC-PD-L1 expression (P = 0.001) and its expression intensity (P = 0.002) were significantly correlated with a higher percentage of PD-1 + tumor infiltrating lymphocytes. In univariate survival analysis, TC-PD-L1 and its expression intensity had a significant impact on both DFS (HR 0.203; P = 0.003 and HR 0.320; P = 0.005) and OS (HR 0.147; P = 0.002 and HR 0.322; P = 0.005). Based on the multivariate analysis, PD1 (DFS HR 3.202; P = 0.011, OS HR 2.671; P = 0.027) and TC-PD-L1 (DFS HR 0.174; P = 0.006, OS HR 0.189; P = 0.009) were found to be independent prognostic markers. In the second part, scoring systems were defined based on the expression status of PD1 and PD-L1. Patients with higher scores were expected to have longer DFS and OS. In multivariate analysis, the PD1/TC-PD-L1 (DFS P = 0.001, OS P = 0.003) scoring systems showed superior prognostic effects. Interestingly, at the highest levels of this score, none of the patients experienced recurrence or cancer-caused death.CONCLUSION:
Collectively, this study suggests negative prognostic behaviour for TC-PD-L1 protein and introduces the PD-1/TC-PD-L1 scoring system as a strong prognostic marker in OS and DFS prediction of tongue and larynx HNSCC patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Head and Neck Neoplasms
/
Larynx
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
BMC Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Canada