The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression.
Cancer Metastasis Rev
; 43(2): 823-844, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38238542
ABSTRACT
Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and epigenetic modifications to breast cancer progression has been widely acknowledged, emerging evidence underscores the pivotal role of physical stimuli in driving breast cancer metastasis. In this review, we summarize the changes in the mechanics of the breast cancer microenvironment and describe the various forces that impact migrating and circulating tumor cells throughout the metastatic process. We also discuss the mechanosensing and mechanotransducing molecules responsible for promoting the malignant phenotype in breast cancer cells. Gaining a comprehensive understanding of the mechanobiology of breast cancer carries substantial potential to propel progress in prognosis, diagnosis, and patient treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Disease Progression
/
Tumor Microenvironment
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Cancer Metastasis Rev
/
Cancer and metastasis reviews (Online)
/
Cancer metastasis. rev
Journal subject:
NEOPLASIAS
Year:
2024
Type:
Article
Affiliation country:
United States