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Rare Ophiuroid-Type Steroid 3ß,21-, 3ß,22-, and 3α,22-Disulfates from the Slime Sea Star Pteraster marsippus and Their Colony-Inhibiting Effects against Human Breast Cancer Cells.
Kicha, Alla A; Malyarenko, Timofey V; Kuzmich, Alexandra S; Malyarenko, Olesya S; Kalinovsky, Anatoly I; Popov, Roman S; Tolkanov, Dmitriy K; Ivanchina, Natalia V.
Affiliation
  • Kicha AA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Malyarenko TV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Kuzmich AS; Department of Bioorganic Chemistry and Biotechnology, School of Natural Sciences, Far Eastern Federal University, Russky Island, Ajax Bay, 10, 690922 Vladivostok, Russia.
  • Malyarenko OS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Kalinovsky AI; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Popov RS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Tolkanov DK; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
  • Ivanchina NV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Mar Drugs ; 22(1)2024 Jan 12.
Article in En | MEDLINE | ID: mdl-38248668
ABSTRACT
Two new steroid 3ß,21-disulfates (1, 2) and two new steroid 3ß,22- and 3α,22-disulfates (3, 4), along with the previously known monoamine alkaloid tryptamine (5) were found in the ethanolic extract of the Far Eastern slime sea star Pteraster marsippus. Their structures were determined on the basis of detailed analysis of one-dimensional and two-dimensional NMR, HRESIMS, and HRESIMS/MS data. Compounds 1 and 2 have a Δ22-21-sulfoxy-24-norcholestane side chain. Compounds 3 and 4 contain a Δ24(28)-22-sulfoxy-24-methylcholestane side chain, which was first discovered in the polar steroids of starfish and brittle stars. The influence of substances 1-4 on cell viability, colony formation, and growth of human breast cancer T-47D, MCF-7, and MDA-MB-231 cells was investigated. It was shown that compounds 1 and 2 possess significant colony-inhibiting activity against T-47D cells, while compounds 3 and 4 were more effective against MDA-MB-231 cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Starfish / Breast Neoplasms Limits: Animals / Female / Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2024 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Starfish / Breast Neoplasms Limits: Animals / Female / Humans Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2024 Type: Article Affiliation country: RUSSIA